LactoEye® with Brainberry®

EMPOWERING EYE-BRAIN FITNESS, IMMUNITY & GUT HEALTH FOR ALL AGES!

LACTOEYE® with BRAINBERRY® is a hallmark fusion of Six highly efficacious and evidence-based nutraceuticals, exclusively designed to provide key nutrients that support healthy vision, brain fitness, eye-hand coordination, digestive health & the immune system.

Filters blue light & relieves eye strain
Improves eyesight & visual clarity
Enhances cognitive performance
Improves immune system
Antioxidant protection
Promotes digestive health

[1 BOX 21 sachets]

RM145.00

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BIOACTIVE INGREDIENTS

BILBERON®-25 Bilberry Extract
Powerful Antioxidants For The Eyes

BILBERON®-25 is a highly concentrated bilberry extract made from fresh fruits in northern Europe and standardized to contain at least 25% anthocyanidins by Tokiwa Phytochemicals Japan. Clinically proven to enhance visual performance, maintain healthy blood vessels, and hydrate the eyes, BILBERON®-25 also promotes the re-composition of rhodopsin and provides potent antioxidant properties for optimal eye health. In just under 2 months, BILBERON®-25 has been shown to significantly improve eye dryness and fatigue.[1-4]

XanMax® Marigold Flower Extract
Rich in free-form lutein & zeaxanthin

XanMax® is a patented US extract from Marigold Flowers, standardized to highly bioavailable free-form Lutein and Zeaxanthin, the primary yellow to red pigment macular carotenoids in the retina and lens. Acting as antioxidants and blue light filters [5,6], they improve visual performance, as shown in a meta-analysis of eight randomized control trials [7]. Lutein and Zeaxanthin also increase macular pigment optical density (MPOD) by 40% in 180 days [8], improve visual acuity and memory in 12 months [9,10], and buffer against age-related declines in verbal learning and memory [11].

BRAINBERRY® Aronia Berry Extract
Brain Fitness of All Ages!

Aronia berry (Aronia Melanocarpa), also known as black chokeberry, is a superfruit that contains high levels of polyphenols and antioxidants. These properties have been proven to improve the immune system and brain fitness of all ages[12]. BRAINBERRY® is a patented Aronia berry Extract produced by BioActor BV (Netherlands), standardized to contain a high concentration of anthocyanin ( > 15% cyanidin-3-galactosides). Proven by clinical studies, this nootropic nutraceutical has the capacity to improve cognitive health and memory[13,14,15].

Mode of Action:

1.Crosses the blood-brain barrier, enhancing brain perfusion and oxygen uptake.
2.Enhances neural signaling, leading to faster and more accurate visual processing and task performance, improving eye-hand coordination.[16,17,18,19,20]
3.Maintains optimal level of Brain Derived Neurotrophic Factor (BDNF), an essential protein for brain health involved in neuronal plasticity and neuroprotection mechanism that improve learning and memory. [16,21]

Micro-Encapsulated Probiotics (10 Billion CFU)
Microencapsulation technology

LACTOEYE® with BRAINBERRY® utilizes a high-performance micro-encapsulated probiotics Bifidobacterium longum Rosell®-175, that are highly stable and resistant to gastric acidity, compression and heat shock [22]. This probiotic has been associated with numerous health benefits, such as normalising gastrointestinal transit, inhibiting the growth of harmful bacteria, boosting the immune system, and effectively reducing stress induced gastrointestinal symptoms. [22,23] This probiotic has also been shown to improve gut and cognitive health via the gut-brain axis., enhancing mood and reducing stress related symptoms [24,25,26,27].

LIPOSOMAL VITAMIN C
233% GREATER ABSORPTION and RETENTION
12 TIMES more EFFECTIVE NEURON GROWTH

Liposomal Vitamin C is a highly efficient lipid bilayer-encapsulated form of Vitamin C, [10] that enhances absorption and retention, improving Vitamin C replenishment. [30]

Vitamin C supplementation has generally been shown to:
a)Provide antioxidants protection[31]
b)Protect the lens against UV-induced oxidative damage [31]
c)Protect against cataracts[31]
d)Boost immune system[32]

Recommended For:

Professionals
Students
Athletes
Night drivers
Contact lens wearers
Gamers or Streamers

SUITABLE FOR ALL AGE GROUPS!

CLINICAL REFERENCE

Chu W, Cheung SCM, Lau RAW, et al. Bilberry (Vaccinium myrtillus L.) In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 4. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92770/
Miyake, S., Takahashi, N., Sasaki, M., Kobayashi, S., Tsubota, K. and Ozawa, Y., 2012. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism. Laboratory investigation, 92(1), pp.102-109.
Nomi, Y., Iwasaki-Kurashige, K., & Matsumoto, H. (2019). Therapeutic Effects of Anthocyanins for Vision and Eye Health. Molecules (Basel, Switzerland), 24(18), 3311. https://doi.org/10.3390/molecules24183311
Nakata, A., 2016. The Improvement Effect of Bilberry Extract (BILBERON®)—Containing Diet on Eye Fatigue and Eye Dryness―A Randomized, Double-blind, Placebo-controlledParallel-group Comparison Study―. 薬理と治療, 44(12), pp.1773-1783.
Abdel-Aal, E.S.M., Akhtar, H., Zaheer, K. and Ali, R., 2013. Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health. Nutrients, 5(4), pp.1169-1185.
Ma, L. and Lin, X.M., 2010. Effects of lutein and zeaxanthin on aspects of eye health. Journal of the Science of Food and Agriculture, 90(1), pp.2-12.
Trieschmann M, Beatty S, Nolan JM, Hense HW, Heimes B, Austermann U, et al., Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study. Exp Eye Res 84:718–728 (2007).
Katra Phytochem. (2018). Age-defying Eye Saviors: A new clinical study of XanMax®. Retrieved from: https://www.lehvoss.de/fileadmin/user_upload/italia/Downloads/XanMax.pdf
Richer S, Stiles W, Statkute L, Pulido J, Frankowski J, Rudy D, et al., Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry 75:216–230 (2004).
Renzi-Hammond, L.M., Bovier, E.R., Fletcher, L.M., Miller, L.S., Mewborn, C.M., Lindbergh, C.A., Baxter, J.H. and Hammond Jr, B.R., 2017. Effects of a lutein and zeaxanthin intervention on cognitive function: a randomized, double-masked, placebo-controlled trial of younger healthy adults. Nutrients, 9(11), p.1246.
Lindbergh, C.A.; Renzi-Hammond, L.M.; Hammond, B.R.; Terry, D.P.; Mewborn, C.M.; Puente, A.N.; Miller, L.S. Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial. J. Int. Neuropsychol. Soc. 2017, 1–14.
Pei, R., Liu, J., Martin, D.A., Valdez, J.C., Jeffery, J., Barrett-Wilt, G.A., Liu, Z. and Bolling, B.W., 2019. Aronia berry supplementation mitigates inflammation in T cell transfer-induced colitis by decreasing oxidative stress. Nutrients, 11(6), p.1316.
Bioactor BV. Brainberry® infosheet 2021. (2021) Retreived from: https://www.12taste.com/wp-content/uploads/2021/07/Brainberry%C2%AE-infosheet-2021.pdf
Ahles, S., Stevens, Y.R., Joris, P.J., Vauzour, D., Adam, J., de Groot, E. and Plat, J., 2020. The effect of long-term aronia melanocarpa extract supplementation on cognitive performance, mood, and vascular function: a randomized controlled trial in healthy, middle-aged individuals. Nutrients, 12(8), p.2475.
Smeriglio, A., Barreca, D., Bellocco, E. and Trombetta, D., 2016. Chemistry, pharmacology and health benefits of anthocyanins. Phytotherapy research, 30(8), pp.1265-1286.
Ullah, R., Khan, M., Shah, S.A., Saeed, K. and Kim, M.O., 2019. Natural antioxidant anthocyanins—A hidden therapeutic candidate in metabolic disorders with major focus in neurodegeneration. Nutrients, 11(6), p.1195.
Henriques, J.F., Serra, D., Dinis, T.C. and Almeida, L.M., 2020. The anti-neuroinflammatory role of anthocyanins and their metabolites for the prevention and treatment of brain disorders. International Journal of Molecular Sciences, 21(22), p.8653.
Zhang, J., Wu, J., Liu, F., Tong, L., Chen, Z., Chen, J., He, H., Xu, R., Ma, Y. and Huang, C., 2019. Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review. European Journal of Pharmacology, 858, p.172500.
BioActor BV., (2022). Brainberry improves concentration, eye-hand coordination & problem solving. BioActor BV. Retrieved from https://bioactor.com/brainberry-a-promising-ingredient-for-gaming-supplements/
BioActor BV. New Open Label Study: Brainberry® shows cognitive and performance benefits in professional basketball players. (2022) Retrieved from https://bioactor.com/new-open-label-study-brainberry-improves-cognitive-and-performance-benefits-in-professional-basketball-players/
BioActor BV. New Open Label Study: Brainberry® improves cognitive parameters in young, healthy e-gamers. (2021) Retrieved from https://bioactor.com/new-open-label-study-brainberry-improves-cognitive-parameters-in-young-healthy-e-gamers/
Lallemand, Bifidobacterium Longum Rosell-175. Lallemand Health Solution. 2014. Available from: www.lallemend-health-solutions.com.
Diop, L., Guillou, S., & Durand, H. (2008). Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial. Nutrition research, 28(1), 1-5.
Hemarajata, P.; Versalovic, J. Effects of probiotics on gut microbiota: Mechanisms of intestinal immunomodulation and neuromodulation. Ther. Adv. Gastroenterol. 2013, 6, 39–51.
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J. F., Rougeot, C., Pichelin, M., Cazaubiel, M., & Cazaubiel, J. M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. The British journal of nutrition, 105(5), 755–764. https://doi.org/10.1017/S0007114510004319
Tremblay, A., Lingrand, L., Maillard, M., Feuz, B., & Tompkins, T. A. (2021). The effects of psychobiotics on the microbiota-gut-brain axis in early-life stress and neuropsychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 105, 110142.
Ullah, H., Di Minno, A., Esposito, C., El-Seedi, H. R., Khalifa, S. A., Baldi, A., ... & Daglia, M. (2022). Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression: A monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial. Biomedicine & Pharmacotherapy, 156, 113930.
Davis, J.L., Paris, H.L., Beals, J.W., Binns, S.E., Giordano, G.R., Scalzo, R.L., Schweder, M.M., Blair, E. and Bell, C., 2016. Liposomal-encapsulated ascorbic acid: Influence on vitamin C bioavailability and capacity to protect against ischemia–reperfusion injury. Nutrition and metabolic insights, 9, pp.NMI-S39764.
Weeks, B.S. and Perez, P.P., 2007. Absorption rates and free radical scavenging values of vitamin C-lipid metabolites in human lymphoblastic cells. Medical science monitor, 13(10), pp.BR205-BR210.
Weeks, B. S., & Perez, P. P. (2007). A novel vitamin C preparation enhances neurite formation and fibroblast adhesion and reduces xenobiotic-induced T-cell hyperactivation. Medical science monitor : international medical journal of experimental and clinical research, 13(3), BR51–BR58.
Lim, J.C., Caballero Arredondo, M., Braakhuis, A.J. and Donaldson, P.J., 2020. Vitamin C and the lens: New insights into delaying the onset of cataract. Nutrients, 12(10), p.3142.
Bae, M. and Kim, H., 2020. The role of vitamin C, vitamin D, and selenium in immune system against COVID-19. Molecules, 25(22), p.5346.