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XANTOACTIV FLEXAPRO CAPSULE™

XANTOACTIV FLEXAPRO CAPSULE™
XANTOACTIV FLEXAPRO CAPSULE™
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REIGNITE YOUR JOINT FLEXIBILITY TODAY!

XANTOACTIV FLEXAPRO CAPSULE™ is a fast-acting, broad-spectrum, scientifically-supported solution, natural and safe alternative for the maintenance of Joint health!

[60 capsules]
RM199.00
 

 

6-IN-1 FORMULA, CLINICALLY PROVEN BENEFITS!

XANTOACTIV FLEXAPRO CAPSULE™ packs a powerful punch with its 6 in 1 formula featuring Mangoselect® Mangosteen Extract, UC-II® Chicken Cartilage Extract, ApresFlex® Boswellia Serrata Extract, Celery Seed Extract, Hyaluronic Acid, and Vitamin D3. This potent combination provides broad-spectrum protection against joint pain, supports bone health, and helps maintain healthy uric acid levels.

 

 

MANGOSELECT® MANGOSTEEN EXTRACT (FRANCE)
Relieves Joint Pain As Early As 5 Days!

Mangoselect® is a clinically-proven extract from France containing natural xanthones, α- and γ- mangostin. These xanthones limit inflammation by reducing the production and activity of the inflammatory enzyme COX-2 and the transcription factor NF-kB. They also reduce oxidative stress by limiting the production of reactive oxygen species [1]​.

Fast Fact
Mangoselect® has been proven to reduce joint discomfort by 50% in chronic conditions ( elderly, p<0.001) and 31% in acute conditions ( athletes, p<0.001), with pain relief as early as 5 days! [1]​.

 

AprèsFlex® BOSWELLIA SERRATA EXTRACT (USA)
Relieves Joint Pain As Early As 5 Days!

AprèsFlex® is a patented form of Boswellia serrata extract that improves mobility rapidly and over an extended period of time with just 100mg/day (equiv. 2 capsules). AprèsFlex® targets the 5-LOX and MMP-3 pathways to manage inflammation from aging, intense physical activity, and sports, and delay joint degeneration from a holistic perspective.

Fast Fact

AprèsFlex® has 10 pre-clinical and clinical studies and improves joint comfort in just 5 days [6] with a 40.1% reduction in WOMAC pain score (P<0.0001) , 41.3% reduction in WOMAC stiffness score (P=0.0001) and 38.8% reduction in WOMAC function score (P=0.0001) . AprèsFlex® also induces a 61.7% reduction in WOMAC scores in 90 days (p<0.01) [7]​.

 

UC-II® CHICKEN CARTILAGE EXTRACT (USA)
2 TIMES Better Than GLUCOSAMINE + CHONDROITIN!

UC-II® is a patented form of undenatured type II collagen that comes from chicken cartilage extract and supports joint health. Taking 40mg/day ( equiv. 2 capsules) of UC-II® induces oral tolerance, which engages the immune system in repairing joint cartilage[2].This immune-mediated mechanism reduces the degradation of endogenous type II collagen, supporting healthy joints and allowing the body to rebuild new cartilage[2].

Fast Fact

UC-II® is Two Times Better Than Glucosamine and Chondroitin[3] and has three published clinical studies on healthy subjects [3-5] . Improvement can be seen as early as 30 days ( p<0.05) [4], with a 33% reduction in WOMAC Pain Score, a 40% reduction in VAS Score, and a 20% reduction in LFI Score.

 

 

Celery Seed Extract (FRANCE)
Benefits gout and stabilizes uric acid levels!

Celery Seed has been used for centuries in traditional medicine to treat a variety of ailments including arthritis and gout. Celery seed extract has been found to contain a variety of bioactive compounds, including flavonoids, phthalides, and polyphenols, that may have anti-inflammatory and antioxidant effects [19-21]. Celery Seed Extract is effective in relieving gout and osteoarthritis symptoms by reducing inflammation [21] as well as lowering uric acid levels in the body [21].

 

Hyaluronic Acid (HA)
Advancing joint health through joints lubrication!

Hyaluronic Acid (HA) is a natural compound present in every tissue of the body, with the highest concentrations in cartilage [8]. However, ageing leads to a decrease in HA content which can cause arthritis [9]. Oral HA supplementation is effective in promoting joint health by preventing cartilage degeneration [10,11], protecting cartilage [12,13], relieving synovial inflammation [14], increasing chondrocyte density [15], promoting synovium metabolism [16], normalizing synovial fluid [17], and relieving joint pain [18].

 

Vitamin D3 (Switzerland)
Supports healthy bone and joint function!

Optimal levels of Vitamin D are essential for healthy bone and cartilage metabolism. Insufficient levels can have negative effects on calcium metabolism, osteoblastic activity, matrix ossification, bone density, and articular cartilage turnover [22]. For adults at risk of bone and joint degeneration, daily supplementation of 1000 IU of Vitamin D3 is is recommended to support healthy bone and joint function [23].

 

 

 

Clinical References

  1. Romain C. & Cases J.; 2015; Agro Food Industry Hi Tech; 26(3): 8-13.
  2. Weiner HL, da Cunha AP, Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011;241(1):241-59. Review. PMID: 21488901.
  3. Crowley DC, Lau FC, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009;6(6):312-21.
  4. Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2016; 15: 14. doi:10.1186/s12937-016-0130-8.
  5. Bagchi D, Misner B, Bagchi M, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-110. doi:10.1055/s-0032-1307482.
  6. Vishal AA, Mishra A, Raychaudhuri SP. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-622. doi:10.7150/ijms.8.615.
  7. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin Against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010;7(6):366-377. doi:10.7150/ijms.7.366.
  8. J.R.E. Fraser, T.C. Laurent. Hyaluronan: Its nature, distribution, functions and turnover Journal of Internal Medicine 1997; 242:27-33.
  9. Peixue LING, Hyaluronic Acid [M], Beijing: Chinese light industry press,2000,133-134.
  10. Shimizu C, Kubo T, Hirasawa Y, Coutts RD, Amiel D. Histomorphometric and biochemical effect of various hyaluronans on early osteoarthritis. J Rheumatol. 1998; 25: 1813–9.
  11. Listrat V, Ayral X, Patarnello F, Bonvarlet JP, Simonnet J, Amor B, et al. Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee. Osteoarthritis Cartilage. 1997; 5: 153–60.
  12. Ghosh P, Holbert C, Read R, Armstrong S. Hyaluronic acid (hyaluronan) in experimental osteoarthritis. J Rheumatol Suppl. 1995; 43: 155–7.
  13. Wenz W, Breusch SJ, Graf J, Stratmann U. Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy. J Orthop Res. 2000; 18: 604–12.
  14. Frizziero L, Govoni E, Bacchini P. Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: clinical and morphological study. Clin ExpRheumatol. 1998; 16: 441–9.
  15. Guidolin DD, Ronchetti IP, Lini E, Guerra D, Frizziero L. Morphological analysis of articular cartilage biopsies from a randomized, clinical study comparing the effects of 500–730 kDa sodium hyaluronate (Hyalgan) and methylprednisolone acetate on primary osteoarthritis of the knee. Osteoarthritis Cartilage. 2001; 9: 371–81.
  16. Maniwa S, Ochi M, Motomura T, Nishikori T, Chen J, Naora H. Effects of hyaluronic acid and basic fibroblast growth factor on motility of chondrocytes and synovial cells in culture. Acta Orthop Scand. 2001; 72: 299–303.
  17. Asari A, Miyauchi S, Matsuzaka S, Ito T, Kominami E, Uchiyama Y. Molecular eight-dependent effects of hyaluronate on the arthritic synovium. Arch Histol Cytol. 1998; 61: 125–35.
  18. Day R, Brooks P, Conaghan PG, Petersen M. A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee. J Rheumatol. 2004; 31: 775–82.
  19. Ferreres F, et al. "Phenolic Composition of Celery Leaves and Stems (Apium graveolens L.) and Its Impact on Antioxidant and Anti-Inflammatory Activities." Journal of Evidence-Based Complementary & Alternative Medicine. 2015; 20(1): 7-13. doi: 10.1177/2156587214554952.
  20. Sowbhagya HB. "Chemistry, Technology, and Nutraceutical Functions of Celery (Apium graveolens L.): An Overview." Molecules. 2019; 24(16): 2965. doi: 10.3390/molecules24162965.
  21. Ghasemzadeh Rahbardar M, et al. "Efficacy of Celery Seed Extract in Patients with Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial." Journal of Medicinal Food. 2013;16(7): 584-589. doi: 10.1089/jmf.2012.2664.
  22. Gröber et al. (2013) Gröber U, Spitz J, Reichrath J, Kisters K, Holick M. Vitamin D Update 2013: from rickets prophylaxis to general preventive healthcare. Dermato-endocrinology. 2013;5(3):331–347. doi: 10.4161/derm.26738.
  23. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D. National Academies Press (US); 2011.

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