Preserving Immunity Holistically

  • 100% DNA Certified
  • 100% Agaratine Free
  • 100% American Grown
  • 100% USDA Certified Organic Ingredient
  • 100% Vegetarian
  • 100% Free from Heavy Metals, Chemicals & Pesticides
  • Full Spectrum, rich in Beta-glucans


Many scientific studies have proven the legendary effects of mushrooms on the improvement of health, vitality and the body’s resistance against chronic diseases. Mushrooms contain a variety of phytochemicals which have powerful immune system enhancement properties. [1].


Agaricus blazei Murrill (ABM)

Amongst the edible mushrooms which are found to have medicinal properties, Agaricus Blazei Murill (commonly known as Agaricus Brazil Mushroom) has become increasingly popular because of its ability to not only boost, but also balance immunity. ABM is originated from Piedade, a small village in the highland areas of Atlantic forest in the province of Sao Paolo, Brazil. The people from this rural area are known to live longer and healthier lives than the average population in the whole of Brazil. When the Government studied the demographics of this region, they found that ABM is a common part of the villagers’ diet.

Over the last decade, ABM (also known as Himematsutake in Japan), is widely used in Japan, United states, Korea, China and Taiwan as a nonprescriptive alternative remedy for the prevention of a wide range of health challenges including cancer, diabetes, atherosclerosis, hypercholesterolemia and chronic hepatitis. In addition to heightening the immune system, ABM is also believed to elicit positive effects on inflammatory bowel syndromes.


Health Benefits of ABM

  • Antioxidant protection.
  • Cardiovascular protection.
  • Gastrointestinal tract protection.
  • Improves immune system.
  • Protects skin against UV damage.
  • Improves glycaemic & lipid control.
  • Improves bowel movement.


Beta Glucans & Immune system

ABM is one of the most potent medicinal mushrooms discovered to-date. ABM is packed with a plethora of phytonutrients (approximately 192 types), essential vitamins, antioxidants, and it is exceptionally rich with polysaccharides particularly the β-glucans 1,3⁄1-6.

Scientific findings significantly suggest that the beta-glucans in ABM are notably powerful in combating cancer cells, viral and bacterial infections. The β-glucans 1,3⁄1-6 activates the immunity response and simulates the production of mutation-fighting cells e.g. Natural Killer (NK) cells, Lymphocyte T-cells, Helper T-cells, interferon and interleukin, that strengthen and maintain a healthy immune system. In a human-based study, ABM has been shown to increase NK cell activities in cancer patients [2]

Due to their low molecular weight, beta-glucans from ABM can be absorbed into the body faster than beta-glucans from yeast and other mushrooms, and thus, this prompt absorption rate confirms their unrivalled effectiveness. In a clinical study presented at a convention by the Japanese Cancer Association in 1980, ABM was reported to have higher levels of beta-glucan and to have shown more antitumor activities more than maitake, shiitake, or reishi mushrooms[3].


Antidiabetic & Insulin-resistance

In a clinical trial conducted in Taipei Hospital in Taiwan, 72 selected patients with type 2 diabetes patients were each asked to take one capsule containing 500 mg of either ABM or placebo three times each day for 12 weeks. The capsule was taken with gliclazide 30 minutes before eating and metformin was taken 30 minutes after eating. At the end of the study, it was demonstrated that subjects who received the ABM supplement showed a significant improvement in insulin resistance, with significant reduction in HOMA-IR index [Homeostasis model assessment for insulin resistance] from 4.8 to 3.6, which was much lower than that observed among the controlled subjects from 6.3 to 6.6.

When compared to the placebo group, it was interesting to note that the subjects who had taken an ABM supplement for 12 weeks showed a significant increase in plasma Adiponectin concentrations. Many past studies reported that the Adiponectin level may be a major modulator of insulin resistance [4] and a predictor in the development and progression of type 2 diabetes [5-7]. Circulating Adiponectin levels in human is positively correlated with insulin sensitivity. The level of adiponectin appeared to play an important role in regulating insulin acting and energy homeostasis [8-9]. After the 12 weeks of ABM treatment, scientists observed a 20% increase in adiponectin level [10]. Thus, this accounts for the improvements in insulin resistance in the group that consumed the ABM supplement.



Cardiovascular health
Adiponectin "The missing link"

Clinical studies suggest that the adipose tissue does not only store energy but also secretes Adiponectin, an important signalling protein derived from the adipose tissue and that is abundantly present in the human plasma . Adiponectin production is inversely correlated with adipose tissue mass [11] and there is a growing number of evidence that shows Adiponectin regulating both lipid and carbohydrate metabolism.

Low Adiponectin levels are found in subjects with obesity, diabetes mellitus and cardiovascular disease (CVD) [12-13]. Subjects with low Adiponectin levels fail some of the protective actions of Adiponectin, including the stimulation of fatty acid oxidation and the improvement of glucose metabolism. In addition, adiponectin inhibits the inflammatory process and possibly atherosclerosis too by suppressing tumour necrosis factor-α-induced adhesion molecule expression, the adhesion and migration of monocytes/macrophages, and prevents their transformation into foam cells [14].

Adiponectin has also been reported to directly and indirectly modulate plasma lipid levels. Several studies have reported a negative correlation of Adiponectin levels with serum triglycerides (TGs) and low density lipoprotein (LDL), and a positive correlation with high density lipoprotein-cholesterol (HDL) [15]. ABM boosts Adiponectin levels in the body, thus, contributing to its cardiovascular protective benefits.


Potential Liver protection

ABM also offers potential benefits for patients with hepatitis B by normalizing liver function. Supplementation of 1500mg / day of ABM for 12 months showed decrease levels of aspartate aminotransferase from 246.0 (± standard deviation [SD] 138.9) to 61.3 (± SD 32.6) IU/L and alanine aminotransferase decreased 151.0 (± SD 86.9) to 46.1 (± SD 22.5) IU/L, respectively in patients with hepatitis B. Controlled studies with larger samples should be conducted in the future to further conclude the hepatoprotective benefits of ABM [16].


Anti-inflammatory effect

The results of a clinical pilot study conducted on patients with inflammatory bowel diseases, ulcerative colitis and Crohn's disease not only showed a significant decrease in plasma levels of pro-inflammatory cytokines after consuming ABM but also decreased levels of the inflammatory marker calprotectin in faeces of ulcerative colitis patients. These anti-inflammatory properties of ABM may also contribute to the mushroom’s therapeutic effect on allergy, and it may potentially be used against autoimmune diseases [4].



  1. C. U. Lima, C. O. Cordova, O. D. Nóbrega, S. S. Funghetto, and M. G. Karnikowski, “Does the Agaricus blazei Murill mushroom have properties that affect the immune system? an integrative review,” Journal of Medicinal Food, vol. 14, no. 1-2, pp. 2–8, 2011.
  2. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP Int J Gynecol Cancer. 2004 Jul-Aug; 14(4):589-94.
  3. T. Mizuno, T. Hagiwara, T. Nakamura et al., “Antitumor activity and some properties of water-soluble polysaccharides from ‘Himematsutake’, the fruiting body of Agaricus blazei Murill,” Agricultural and Biological Chemistry, vol. 54, pp. 2889–2896, 1990.
  4. Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinne- mia in obesity and type 2 diabetes: Closed association with in- sulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001;86:1930–1935.
  5. Spranger J, Kroke A, Mohlig M, et al. Adiponectin and pro- tectin against type 2 diabetes. Lancet 2003;361:226–228.
  6. Lindsay RS, Funahahi T, Hanson RL, et al. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 2002;360:57–58.
  7. Daimon M, Oizumi T, Saitoh T, et al. Decreased serum levels of adiponectin are a risk factor for progression to type 2 diabetes in Japanese population: The Funagata study. Diabetes Care 2003;26:2015–2020.
  8. Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: Leptin, acylation stimulating protein and adiponectin. Lipidology 2002;13:51–59.
  9. Mattthias BS, Eris S, Nader R, Frank BH. Relationship be- tween adiponectin and glycemic control, blood lipids and in- flammatory markers in men with type 2 diabetes. Diabetes Care 2004;27:1680–1687.
  10. Hsu CH et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE 2007 Jan-Feb;13(1):97-102.
  11. Yamauchi, T., J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, S. Uchida, S. Yamashita, M. Noda, S. Kita, K. Ueki, et al. 2002. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8: 1288–1295.
  12. Kumada, M., S. Kihara, S. Sumitsuji, T. Kawamoto, S. Matsumoto, N. Ouchi, Y. Arita, Y. Okamoto, I. Shimomura, H. Hiraoka, et al. 2003. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler. Thromb. Vasc. Biol. 23: 85–89.
  13. Ouchi, N., S. Kihara, Y. Arita, K. Maeda, H. Kuriyama, Y. Okamoto, K. Hotta, M. Nishida, M. Takahashi, T. Nakamura, et al. 1999. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation. 100: 2473–2476.
  14. Shimada, K., T. Miyazaki, and H. Daida. 2004. Adiponectin and atherosclerotic disease. Clin. Chim. Acta. 344: 1–12
  15. Baratta, R., S. Amato, C. Degano, M. G. Farina, G. Patane, R. Vigneri, and L. Frittitta. 2004. Adiponectin relationship with lipid metabolism is independent of body fat mass: evidence from both cross-sectional and intervention studies. J. Clin. Endocrinol. Metab. 89: 2665–2671.
  16. Chung-Hua Hsu et al. 2008. The Mushroom Agaricus blazei Murill Extract Normalizes Liver Function in Patients with Chronic Hepatitis B. J. Alternative & Complementary Medicine Vol. 14, No.3 .


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