Osteoarthritis (OA) is a degenerative joint disorder and is the most type of arthritis suffered by the old and the obese. Joint deterioration and inflammation are direct results of increased aging-related stress and the wear and tear of joints.
Osteoarthritis is brought about by cartilage breakdown and synovial proliferation which cause much pain and joint stiffness. Thus, OA sufferers are confined to an almost inoperative lifestyle as their condition worsens with physical activities.
5-LOX & MMP-3 - The key enzymes involved in Osteoarthritis (OA) & Rheumatoid Arthritis (RA).
5-LOX is a member of the lipoxy-genase family of enzymes. 5-LOX itself facilitates undesirable cell division changes, It also plays a key role in the biosynthesis of pro-inflammatory compounds ( leukotrienes) that mediate attacks to joints, arterial walls, and other tissues. The typical modern diet rich red meat, poultry, eggs and dairy products, trigger the body to produce more 5-LOX, worsening the inflammation progress.
Matrix metalloproteinase 3 (MMP-3) is an enzyme that breakdown proteins and peptides in the synovial tissues in response to inflammation, and that leads to cartilage destruction in RA and OA. In the extracellular space, MMP-3 triggers microglia to produce pro-inflammatory and cytotoxic molecules which further degrade cartilage matrix and other components of connective tissue in the joints.
In recent years, the gum resin extracted from the ancient plant, Boswellia Seratta, has gained considerable attention as a potent anti-inflammatory, anti-arthritic agent. 3-0-acetyl-11-keto-beta boswellic acid (AKBA) is the most active compound of Boswellia extract and is a potent inhibitor of 5-lopoxygenase (5-LOX) and MMP-3.
TRUFLEX is formulated with clinically proven Boswellia serrata gum resin extract rich in AKBA. Unlike other Boswellia serrata extracts which have poorer bioavailability, TRUFLEX employs a patented enrichment process, selecting the most active AKBA and blend it with the know-how Boswellia seratta non-volatile oil extract. This synergistic composition results at least 20% bioactive AKBA for direct absorption, making TRUFLEX a more powerful ingredient for overall joint health, far more efficacious compared to the existing Boswellia extracts