{"id":8190,"date":"2025-08-29T07:09:23","date_gmt":"2025-08-29T07:09:23","guid":{"rendered":"https:\/\/lifefactor.my\/?p=8190"},"modified":"2026-02-24T23:56:19","modified_gmt":"2026-02-24T15:56:19","slug":"coenzyme-q10-science-over-hype-2","status":"publish","type":"post","link":"https:\/\/lifefactor.my\/zh\/2025\/08\/29\/coenzyme-q10-science-over-hype-2\/","title":{"rendered":"\u8f85\u9176 Q10\uff1a\u79d1\u5b66\u80dc\u8fc7\u7092\u4f5c"},"content":{"rendered":"<p><b>What is CoQ10?<\/b><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">CoQ10 is a powerful antioxidant naturally produced in our cells, essential for energy production at the cellular level. It works in the mitochondria \u2014 the \u201cpower house of cells\u201d \u2014 as part of the electron transport chain to generate ATP (adenosine triphosphate), the body\u2019s main energy source. [1]<\/span><\/p>\n<p><b>CoQ10 and aging<br \/>\n<\/b><span style=\"font-weight: 400;\">As we age, the body&#8217;s natural production of CoQ10 gradually declines, leading to reduced cellular energy. This decline can contribute to fatigue, poor concentration, or muscle weakness.[2] CoQ10 levels begin to drop in our 30s, decrease by about &gt;30% in our 40s, and by age 60s may fall by as much as 50%, especially in energydemanding organs like the heart &amp; muscle. [3]<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CoQ10 levels are further depleted in certain groups, making supplementation even more important. These groups include athletes, highly active individuals, cardiovascular patients, those taking statins, smokers, and individuals under chronic stress.<br \/>\n<\/span><\/p>\n<p><b>Ubiquinone vs Ubiquinol<\/b><\/p>\n<p><span style=\"font-weight: 400;\">CoQ10 exists in two redox bioactive forms in the body:<\/span><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\"> Ubiquinone (oxidized form)<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> Ubiquinol (reduced form)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Once ingested, regardless of ubiquinone or ubiquinol, it will reach into an equilibrium and two forms are easily, interchangeably converted <\/span><span style=\"font-weight: 400;\">depending on the redox state. [4]\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Remember that CoQ10 occurs naturally in the body, where it shifts between its ubiquinone and ubiquinol form in a continuous cycle.When we take an ubiquinone supplement, our body converts it to ubiquinol and back again. So regardless of what form of CoQ10 we take, our body will convert it to the other form as needed. <\/span><\/p>\n<p><b>Is ubiquinol better than ubiquinone?<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Some manufacturers have claimed that the reduced form of CoQ10 (ubiquinol) is more readily absorbed in the gastrointestinal tract. [5]Some people assume that taking supplemental CoQ10 in its ubiquinol form may enhance absorption. This concept, widely disseminated on the Internet, seems in part to have originated from an inappropriate comparison of bioavailability data from other studies. <\/span><\/p>\n<p><b>What does science say? <\/b><\/p>\n<p><span style=\"font-weight: 400;\">Scientific literature reiterating both ubiquinol and ubiquinone are a redox pair, readily interchange into each other within the body.[6,7] Importantly, many scientific studies have reported no significant difference in the relative bioavailability of ubiquinone and ubiquinol supplements. [8,9]Thus, the claims of superior bioavailability for supplemental ubiquinol over ubiquinone are not supported by current clinical evidence. [10]\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While some manufacturers promote ubiquinol as a \u201cmore active\u201d or \u201cbetter absorbed\u201d form, this is not substantiated by the majority of independent research. [11]Ubiquinol is inherently unstable and will oxidize to ubiquinone the gastrointestinal tract. In summary, misinterpretation of CoQ10\u2019s redox behaviour and bioavailability has led to incorrect marketing claims about the superiority of one form over the other. <\/span><\/p>\n<p><b>CoQ10 absorption and transport in body<\/b><\/p>\n<p><span style=\"font-weight: 400;\">CoQ10 can be supplemented as either ubiquinone or ubiquinol, but regardless of which form is ingested, it is absorbed in the small intestine predominantly as ubiquinone, after solubilization into micelles with dietary fats and bile salts. Once incorporated into chylomicrons and transported via the lymphatic system, much of the absorbed CoQ10 is converted to ubiquinol, [12]which is the dominant circulating form in plasma. In this state, it serves as a potent antioxidant, protecting blood lipids and cell membranes from oxidative damage. Within cells, particularly in the mitochondria, CoQ10 undergoes redox cycling, converting back to ubiquinone in the inner mitochondrial membrane, where it plays a critical role in ATP production and supporting mitochondrial biogenesis, enabling cells to meet the high energy demands of organs such as the heart, brain, and skeletal muscles. [13,14]\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-000.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-8183 alignnone\" src=\"https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-000-200x300.jpg\" alt=\"\" width=\"200\" height=\"300\" srcset=\"https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-000-200x300.jpg 200w, https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-000.jpg 482w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/><\/a><\/p>\n<p><b>Formulation matters! <\/b><\/p>\n<p><span style=\"font-weight: 400;\">Regardless of whether CoQ10 is taken as ubiquinone or ubiquinol, the raw crystalline powder form is poorly absorbed because it has a strong tendency to self-aggregate, which significantly reduces its bioavailability.[15] To enhance absorption, CoQ10 crystals must first be dissociated into single molecules, and most importantly, these molecules need to remain fully dissociated throughout the shelf life of the preparation\u2014something that not all manufacturers have been able to achieve. [15]\u00a0<\/span><\/p>\n<p><b>Ubiqsome\u00ae : The CoQ10 game changer<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Ubiqsome\u00ae is a unique Coenzyme Q10 (ubiquinone) formulation enhanced with Indena\u00ae Phytosome\u00ae technology from Italy, designed to optimize absorption. Phytosome\u00ae is a solid dispersion technology that incorporates CoQ10 into a phospholipid-based delivery matrix. By embedding each CoQ10 molecule within lecithin (phospholipids), this technology prevents clumping (self-aggregation) to enhance stability and improve bioavailability.<\/span><\/p>\n<p><b>Ubiqsome\u00ae is backed by solid science!<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Ubiqsome\u00ae is the first and only CoQ10 formulation in the market clinically proven to reach its biological site \u2013 the mitochondria. Supported by triple pharmacokinetics, Ubiqsome\u00ae improves plasma CoQ10 levels even after a single dose [16] and delivers 9\u00d7 greater bioavailability than unformulated CoQ10. Clinical evidence further shows it provides 4\u00d7 higher CoQ10 concentrations in muscle tissue [17,18], supporting physical performance and exercise recovery. Ubiqsome\u00ae achieves 12\u00d7 greater mitochondrial uptake, ensuring efficient cellular energy production. Additionally, Ubiqsome\u00ae improves endothelial functions and cardiovascular health [19] and helps relieve statininduced muscle weakness (asthenia) while improving strength [20] .\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-001.jpg\"><img decoding=\"async\" class=\"alignnone size-medium wp-image-8184\" src=\"https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-001-300x89.jpg\" alt=\"\" width=\"300\" height=\"89\" srcset=\"https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-001-300x89.jpg 300w, https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-001-600x178.jpg 600w, https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Q10-Scientific-communication-edited.pdf-image-001.jpg 765w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p><b>Ubiqsome\u00ae + Quercefit\u00ae \u2014 the perfect match\uff01<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Ubiqsome\u00ae and Quercefit\u00ae (Quercetin Phytosome\u00ae) form a powerful combination that supports heart health, enhances energy metabolism, and improves physical performance. Together, they deliver potent antioxidant and anti-inflammatory protection, while Quercefit\u00ae also supports immune health with anti-allergic, antihistamine, and antiviral properties.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When one plus one equals more than two \u2014 that\u2019s the power of synergy. This unique pairing helps increase stamina, reduce fatigue, and accelerate recovery, making it an ideal solution for athletes and active individuals seeking optimal performance.\u00a0<\/span><\/p>\n<p><b>For real results, trust the science behind the formulation<\/b><\/p>\n<p><span style=\"font-weight: 400;\">CoQ10 is a remarkable nutrient\u2014but its effectiveness depends on how it&#8217;s delivered. Choosing the right formulation, not just the right form, is key to getting real benefits. Always look for clinically studied CoQ10 with proven absorption, stability, and efficacy.<\/span><\/p>\n<p>References:<\/p>\n<ol>\n<li>\u00a0Littarru, G. P., &amp; Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular Biotechnology, 37(1), 31\u201337<\/li>\n<li>Barcelos, I. P. D., &amp; Haas, R. H. (2019). CoQ10 and aging. Biology, 8(2), 28.<\/li>\n<li>Hoppe, U., Bergemann, J., Diembeck, W., Ennen, J., Gohla, S., Harris, I., &#8230; &amp; Steckel, F. (1999). Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors, 9(2\u20104), 371-378.<\/li>\n<li>Pelton, R. (2020). Coenzyme Q10: A miracle nutrient advances in understanding. Integrative Medicine: A Clinician&#8217;s Journal, 19(2), 16<\/li>\n<li>Mantle, D., &amp; Dybring, A. (2020). Bioavailability of coenzyme Q10: An overview of the absorption process and subsequent metabolism. Antioxidants, 9(5), 386.<\/li>\n<li>Bentinger, M., Brismar, K., and Dallner, G., The antioxidant role of coenzyme Q. Mitochondrion, 7S, S41\u201350 (2007).<\/li>\n<li>Crane, F. L., Biochemical functions of coenzyme Q10. J. Am. Coll. Nutr., 20, 591\u2013598 (2001).<\/li>\n<li>Lopez-Lluch G (2019) The important role of CoQ10 in aging. Antioxidants (Basel) 8(12).<\/li>\n<li>Zozina VI, Covantev S, Goroshko OA, Krasnykh LM, Kukes VG (2018) Coenzyme Q10 in cardiovascular and metabolic diseases: current state of the problem. Curr Cardiol Rev 14(3):164\u2013174.<\/li>\n<li>Bhagavan, H. N., &amp; Chopra, R. K. (2007). Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion, 7, S78-S88.<\/li>\n<li>Mantle, D., &amp; Dybring, A. (2020). Bioavailability of coenzyme Q10: An overview of the absorption process and subsequent metabolism. Antioxidants, 9(5), 386.<\/li>\n<li>L\u00f3pez-Lluch, G.; Del Pozo-Cruz, J.; S\u00e1nchez-Cuesta, A.; Cort\u00e9s-Rodr\u00edguez, A.B.; Navas, P. Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition 2019, 57, 133\u2013140.<\/li>\n<li>Crane, F. L. (2001). Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition, 20(6), 591-598.<\/li>\n<li>Schulz, C., Oberm\u00fcller-Jevic, U. C., Hasselwander, O., Bernhardt, J., &amp; Biesalski, H. K. (2006). Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu\u2122 Q10). International journal of food sciences and nutrition, 57(7-8), 546-555.<\/li>\n<li>Littarru, G. P., &amp; Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular biotechnology, 37(1), 31-37.<\/li>\n<li>Petrangolini, Giovanna, et al. &#8220;A New Food-grade Coenzyme Q10 Formulation Improves Bioavailability: Single and Repeated Pharmacokinetic Studies in Healthy Volunteers.&#8221; Current drug delivery (2019).<\/li>\n<li>Drobnic, Franchek, et al. &#8220;Efficient muscle distribution reflects the positive influence of coenzyme Q10 Phytosome in healthy aging athletes after stressing exercise.&#8221; Journal of Food Science and Nutrition Research, 2020, vol. 3, num. 4, p. 262-275 (2020).<\/li>\n<li>Paredes-Fuentes, Abraham J., et al. &#8220;Coenzyme Q10 treatment monitoring in different human biological samples.&#8221; Antioxidants 9.10 (2020): 979.<\/li>\n<li>Cicero, A. F., Fogacci, F., Di Micoli, A., Veronesi, M., &amp; Borghi, C. (2022). Noninvasive instrumental evaluation of coenzyme Q10 phytosome on endothelial reactivity in healthy nonsmoking young volunteers: A double\u2010blind, randomized, placebo\u2010controlled crossover clinical trial. Biofactors, 48(5), 1160-1165.<\/li>\n<li>Drobnic, F., Riera Riera, J., Artuch Iriberri, R., Jou, C., Codina, A., Montero, R., &#8230; &amp; Togni, S. (2020). Efficient muscle distribution reflects the positive influence of coenzyme Q10 Phytosome in healthy aging athletes after stressing exercise. Journal of Food Science and Nutrition Research, 2020, vol. 3, num. 4, p. 262-275.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is CoQ10? CoQ10 is a powerful antioxidant naturally produced in our cells, essential for energy production at the cellular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8189,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[77],"tags":[],"class_list":["post-8190","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Coenzyme Q10: Science Over Hype - Life Factor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lifefactor.my\/zh\/2025\/08\/29\/coenzyme-q10-science-over-hype-2\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Coenzyme Q10: Science Over Hype - Life Factor\" \/>\n<meta property=\"og:description\" content=\"What is CoQ10? CoQ10 is a powerful antioxidant naturally produced in our cells, essential for energy production at the cellular [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lifefactor.my\/zh\/2025\/08\/29\/coenzyme-q10-science-over-hype-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Life Factor\" \/>\n<meta property=\"article:published_time\" content=\"2025-08-29T07:09:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T15:56:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lifefactor.my\/wp-content\/uploads\/2025\/08\/Untitled-design-2025-08-29T150530.870.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 \u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/lifefactor.my\\\/zh\\\/2025\\\/08\\\/29\\\/coenzyme-q10-science-over-hype-2\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lifefactor.my\\\/zh\\\/2025\\\/08\\\/29\\\/coenzyme-q10-science-over-hype-2\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/lifefactor.my\\\/zh\\\/#\\\/schema\\\/person\\\/ecc7a9e031e6149e15ce5a514ddcc857\"},\"headline\":\"Coenzyme Q10: Science Over Hype\",\"datePublished\":\"2025-08-29T07:09:23+00:00\",\"dateModified\":\"2026-02-24T15:56:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/lifefactor.my\\\/zh\\\/2025\\\/08\\\/29\\\/coenzyme-q10-science-over-hype-2\\\/\"},\"wordCount\":1373,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/lifefactor.my\\\/zh\\\/2025\\\/08\\\/29\\\/coenzyme-q10-science-over-hype-2\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/lifefactor.my\\\/wp-content\\\/uploads\\\/2025\\\/08\\\/Untitled-design-2025-08-29T150530.870.png\",\"articleSection\":[\"Articles\"],\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/lifefactor.my\\\/zh\\\/2025\\\/08\\\/29\\\/coenzyme-q10-science-over-hype-2\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/lifefactor.my\\\/zh\\\/2025\\\/08\\\/29\\\/coenzyme-q10-science-over-hype-2\\\/\",\"url\":\"https:\\\/\\\/lifefactor.my\\\/zh\\\/2025\\\/08\\\/29\\\/coenzyme-q10-science-over-hype-2\\\/\",\"name\":\"Coenzyme Q10: Science Over Hype - 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