La Jeunifique™ NMN+

NAD+ and cellular aging

NAD+ (Nicotinamide adenine dinucleotide) is an essential coenzyme that plays a critical role in maintaining various fundamental cellular functions, including anti-aging, DNA repair, genomic stability, cellular senescence, immune cell function, cognitive health, metabolic pathways and energy metabolism.

NAD+ levels decrease gradually as we get older

As we age, our NAD+ levels progressively decrease, dwindling to just half of their youthful levels by the time we reach 40. This decrease in NAD+ levels trigger a reduction in the activity of crucial longevity enzymes, such as Sirtuins and PARP, which impairs the body’s ability to repair DNA damage. Ultimately, this contributes to hallmark signs of aging.

Uthever™ NMN (300mg)
The clinically proven immediate NAD+ precursor

Uthever™ NMN is a patented, high-purity (99%), high-stability, and clinically proven form of NMN that can boost NAD+ levels in human subjects. Among the NAD+ precursors, NMN is considered the most direct and efficient, as it can be transported directly into cells¹⁰, delivering all three molecules (nicotinamide, ribose, and a phosphate group) required for NAD+ synthesis and effectively restores NAD+ levels.

Fast Fact

A clinical trial involving healthy subjects between the ages of 40-65 years, who were administered 300mg of Uthever™ NMN, showed that:

☑ 11.3% increase in serum NAD+ at day 30.

☑ 38% increase in serum NAD+ at day 60.

Belight³™ (300mg)
The Patented Skin Brightening, Dark-Spot Corrector

Belight³™ is a patented nutricosmetic that offers triple-action brightening effects. It comprises a synergistic blend of grape monomers of flavanols, licorice extract, vitamin C, and grape viniferin, which have all been dermatologically tested and clinically proven to be effective. Specifically, Belight³™ is designed to correct hyperpigmentation, lighten dark spots, and regulate melanin overproduction for a more even and radiant complexion.

Grape viniferin is a dimer of resveratrol, consisting of two resveratrol units joined together. Research studies have shown that grape viniferin is four times more potent than kojic acid and resveratrol in hindering the activity of tyrosinase, an enzyme that participates in the production of melanin responsible for skin pigmentation.

A 60-day single-blind, open-label consumer study involving 100 participants (n=100) with skin hyperpigmentation under dermatological control, who were administered 300mg of Belight³™  daily, showed remarkable results:

☑ Even skin tone by 30%

☑ Reduced dark spots in 82% of tested subjects

☑ Decreased tyrosinase activity by 85%

☑ Results seen as early as 10 days of supplementation

☑ Reduced age-related dark sports by 30% (p< 0.0001)

☑ Reduced sun-related dark sports by 40% (p<0.0001)

☑ 65% of subjects noticed a reduction of their dark spots after 15 days

☑ 73% of subjects noticed a reduction of their dark spots after 30 days

☑ 82% of subjects noticed a reduction of their dark spots after 60 days

☑ 94% of subjects considered the benefits were quickly perceived

Scientific References

1. Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 22(2), 119-141.
2. Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.
3. Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2020). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Frontiers in endocrinology, 11, 367. doi: 10.3389/fendo.2020.00367
4. Imai, S. & Guarente, L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 24, 464–471 (2014)
5. Niu, K.-M., Bao, T., Gao, L., Ru, M., Li, Y., Jiang, L., Ye, C., Wang, S., & Wu, X. (2021). The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase. Frontiers in Nutrition, 8, 756243. doi: 10.3389/fnut.2021.756243. PMID: 34912838. PMCID: PMC8667784
6. Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA. The rate of increase of short telomeres predicts longevity in mammals. Cell Rep. 2012;2(4):732-737. doi:10.1016/j.celrep.2012.08.023
7. Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJM, Daubenmier J, et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013 Oct;14(11):1112-1120. doi: 10.1016/S1470-2045(13)70366-8. Epub 2013 Sep 17. PMID: 24051140; PMCID: PMC3943537.
8. Kimura M, Hjelmborg JV, Gardner JP, Bathum L, Brimacombe M, Lu X, Christiansen L, Vaupel JW, Aviv A. Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol. 2008 Feb 1;167(3):799-806. doi: 10.1093/aje/kwm359. Epub 2007 Dec 11. PMID: 18073339; PMCID: PMC2649981.
9. Morita, Y., Izawa, H., Hirano, A., Mayumi, E., Isozaki, S., & Yonei, Y. (2022). Clinical evaluation of changes in biomarkers by oral intake of NMN. Glycative Stress Research, 9(2), 33-41.
10. Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., ... & Imai, S. (2019). Slc12a8 is a nicotinamide mononucleotide transporter. Nature Metabolism, 1(1), 47-57. doi: 10.1038/s42255-018-0009-4.
11. Apte, R.S., Uchida, K. and Yoshino, J. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism, 24(6), 795-806.
12. Kim, D. H., Ryu, D., Kang, Y., Kim, H. J., Ahn, Y. J., Lee, Y. H., ... & Choi, K. M. (2022). A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults. Frontiers in Aging, Section Nutrition in Aging and Healthy Longevity, 3, 851698. doi: 10.3389/fragi.2022.851698.
13. Feng, Y., He, X., Yang, Y., Chao, Y., Liu, D., & Guo, Y. (2013). Grapevine resveratrol monomers and oligomers profiling and their SIRT1 and antioxidant activities. Food chemistry, 136(2), 643-649. doi: 10.1016/j.foodchem.2012.08.004.
14. Malinowska, M. A., Billet, K., Drouet, S., Munsch, T., Unlubayir, M., Tungmunnithum, D., Giglioli-Guivarc’h, N., Hano, C., & Lanoue, A. (2021). Grape Cane Extracts as Multifunctional Rejuvenating Cosmetic Ingredient: Evaluation of Sirtuin Activity, Tyrosinase Inhibition and Bioavailability Potential. Molecules (Basel, Switzerland), 26(6), 1707. doi: 10.3390/molecules26061707
15. Fu, J.; Jin, J.; Cichewicz, R.H.; Hageman, S.A.; Ellis, T.K.; Xiang, L.; Peng, Q.; Jiang, M.; Arbez, N.; Hotaling, K.; et al. Trans-(-)-ε-viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated Protein Kinase (AMPK), and protects cells in models of huntington disease. J. Biol. Chem. 2012, 287, 24460–24472.
16. Grant R. Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of the NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase. Nat. Preced. 2010;4421:1–8. doi: 10.1038/npre.2010.4421.1.